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. 2020 Mar 31;122(10):1428–1440. doi: 10.1038/s41416-020-0823-9

Fig. 2. Key signalling pathways that support liver cancer stem cell properties and their association with liver cancer stem cell marker expression.

Fig. 2

Wnt/β-catenin and IL-6/STAT3 are the two main signalling pathways that support liver cancer stemness. Recent studies have provided additional evidence that MAPK signaling, NF-κB signaling, Hippo signaling, and Notch signaling are also playing critical roles in supporting liver cancer stemness and associated with the elevated expression of the indicated liver cancer stem cell markers.