Table 1.

Basic characteristics of AD patients (n = 54) underwent next-generation sequencing analysis.

	Early onset (n = 22)	Late onset (n = 32)	P value
Age (year)	60.86 ± 3.22	76.28 ± 5.77	<0.001
Gender (male)	8 (36.4%)	9 (28.1%)	0.563
Education (year)	8.88 ± 3.83	6.38 ± 4.95	0.084
Self-antigen load	6115 ± 2430	4373 ± 2492	0.011
High self-antigen load	21 (95.5%)	20 (62.5%)	0.008
ApoE (ε4 + )	7 (31.8%)	16 (50.0%)	0.264
Baseline CDR (0.5 or 1)	15 (68.2%)	31 (96.9%)	0.006