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. 2020 May 12;10:7832. doi: 10.1038/s41598-020-64828-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of intracellular DOX and CUR concentration in lymphoma cells, along with epigenetic affect on miRNAs. (A) Confocal microscopy results (40×) of CUR and DOX signal on BJAB cell incubated with different drugs for 3 h. The groups are DOX group, DOX + CUR group, L-DOX group and L-DOX + CUR group. (B) miRNA levels were also tested in L-DOX vs LDOX + CUR groups by quantitative RT-PCR. All groups take the final dose equal to 5 μM DOX and 6.15 μM CUR. *p < 0.01.