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. 2020 May 12;10:7832. doi: 10.1038/s41598-020-64828-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo efficacy studies. (A) Change of tumor volume demonstrates the inhibition of BJAB bearing SCID mice xenograft. (DOX 9 mg/kg). (B) Growth rate of tumor volume demonstrated the inhibition of BJAB bearing SCID mice xenograft. (DOX 9 mg/kg). (C) Gross view and HE staining results of the tumors. (D) weight change rate of BJAB bearing SCID mice during treatment. (A,B) One-way ANOVA test, between groups, *indicates P < 0.05, **indicates P < 0.001. (D) Due to the death on the 12th day, the mice died, so the weight change analysis, the data was weighed until the 10th day. After one-way analysis of variance, each treatment group and the control group were compared. **Indicates P < 0.01, ***indicates P < 0.001 when compared with the treatment group. *Indicates P < 0.05. When the DOX group was compared with the L-DOX group, P = 0.013, and the DOX group also decreased compared with the L-DOX + CUR group, P = 0.016.