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. 2020 May 12;3:235. doi: 10.1038/s42003-020-0932-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Histone and DNA modifications. TADs are higher in repressive and lower in active chromatin marks compared to inter-TAD regions. b Transposable element (TE) permutation analysis. Most TE classes are overrepresented in TADs. Green line—observed number of overlaps, grey line—mean of simulated overlaps, red line—significance threshold. Thousand permutations were performed. c Recombination rate. Recombination rate is significantly higher in TADs compared to inter-TAD regions. d Number of meiotic crossovers. Meiotic crossovers are significantly overrepresented in TADs. Green line—observed number of overlaps, grey line—mean of simulated overlaps, red line—significance threshold. *p < 0.01, two-tailed Wilcoxon rank sum test, statistical tests were performed on non-log-transformed values. Center line, median; box limits, upper and lower quartiles; whiskers, 1.5× interquartile range; points, outliers.