Table 3.
Genotype and allele frequencies of four SNPs in T2DM patientsand controls.
| SNPs | Genotypes and Alleles | Frequencies n (%) | OR(95%CI)* | P-values | HWE test | |
|---|---|---|---|---|---|---|
| T2DM patients (n = 681) | Controls(n = 690) | |||||
| T-778C rs805296 | TT | 339 (49.8) | 422 (61.2) | 1.00 | <0.001 | 0.369 |
| TC | 270 (39.6) | 230 (33.3) | 1.24 (1.02–1.56) | |||
| CC | 72 (10.6) | 38 (5.5) | 1.83 (1.24–2.51) | |||
| TC + CC | 342 (50.2) | 268 (38.8) | 1.29 (1.10–1.66) | <0.001 | ||
| T | 948 (69.6) | 1074 (77.8) | <0.001 | |||
| C | 414(30.4) | 306 (22.2) | ||||
| C-1065A rs805297 | GG | 359 (52.7) | 396 (57.4) | 1.00 | 0.119 | 0.147 |
| GT | 256 (37.6) | 244 (35.4) | 1.06 (0.95–1.37) | |||
| TT | 66 (9.7) | 50 (7.2) | 1.10 (0.86–1.61) | |||
| GT + TT | 322 (47.3) | 294 (42.6) | 1.07 (0.92–1.43) | 0.082 | ||
| G | 974 (71.5) | 1036 (75.1) | 0.035 | |||
| T | 388 (28.5) | 344 (24.9) | ||||
| −724 ins/del | Ins/ ins | 346 (50.8) | 431 (62.5) | 1.00 | <0.001 | 0.631 |
| Ins/ del | 276 (40.5) | 226 (32.8) | 1.61 (1.38–1.89) | |||
| Del/ del | 59 (8.7) | 33 (4.8) | 2.03(1.62–2.83) | |||
| Ins/ del+Del/ del | 335 (49.2) | 259 (37.5) | 1.66 (1.40–2.06) | <0.001 | ||
| Ins | 968 (71.1) | 1088 (78.8) | <0.001 | |||
| Del | 394(28.9) | 292 (21.2) | ||||
| T-855C rs9404941 | TT | 364 (53.4) | 402 (58.3) | 1.00 | 0.188 | 0.247 |
| TC | 263 (38.6) | 242 (35.1) | 1.08(0.91–1.36) | |||
| CC | 54 (7.9) | 46 (6.7) | 1.04 (0.82–1.53) | |||
| TC + CC | 317 (46.5) | 288 (41.7) | 1.07 (0.89–1.39) | 0.073 | ||
| T | 991 (72.8) | 1046(75.8) | 0.069 | |||
| C | 371 (27.2) | 334(24.2) | ||||
*Adjusted for gender, age, smoke and alcohol consumption status, high fat diet, low fiber diet, TC and HDL.