Table 1.
Univariate survival analysis between overall TILs and various immune cell markers with the local recurrence free interval in DCIS patients treated with breast conserving surgery.
| Marker | All recurrences | Invasive recurrences | ||||||
|---|---|---|---|---|---|---|---|---|
| Hazard ratio | 95% Confidence interval | p-value | Hazard ratio | 95% Confidence interval | p-value | |||
| Lower | Upper | Lower | Upper | |||||
| Overall TILs | 2.9 | 1.7 | 5.0 | 0.0001 | 2.1 | 1.1 | 4.3 | 0.040 |
| sCD20 | 0.9 | 0.5 | 1.7 | 0.793 | 0.9 | 0.4 | 1.9 | 0.770 |
| sCD3 | 1.1 | 0.6 | 1.9 | 0.877 | 0.8 | 0.4 | 1.7 | 0.563 |
| sCD8 | 0.9 | 0.5 | 1.8 | 0.992 | 0.5 | 0.2 | 1.2 | 0.109 |
| sCD4 | 1.5 | 0.9 | 2.8 | 0.150 | 1.2 | 0.5 | 2.5 | 0.708 |
| sFOXP3 | 2.1 | 1.1 | 3.7 | 0.025 | 1.1 | 0.4 | 2.6 | 0.895 |
| sPD1 | 1.3 | 0.7 | 2.3 | 0.412 | 0.7 | 0.3 | 1.6 | 0.347 |
| sPDL-1 | 4.4 | 2.4 | 8.1 | <0.0001 | 2.4 | 1.1 | 5.3 | 0.032 |
| iCD20 | 1.2 | 0.7 | 2.2 | 0.520 | 1.1 | 0.5 | 2.3 | 0.937 |
| iCD3 | 1.2 | 0.7 | 2.2 | 0.522 | 0.9 | 0.5 | 2.1 | 0.979 |
| iCD8 | 1.1 | 0.6 | 1.9 | 0.839 | 0.7 | 0.3 | 1.7 | 0.529 |
| iCD4 | 1.2 | 0.7 | 2.1 | 0.572 | 1.1 | 0.5 | 2.2 | 0.985 |
| iFOXP3 | 1.6 | 0.8 | 3.3 | 0.180 | 0.7 | 0.2 | 2.5 | 0.617 |
| iPD1 | 0.9 | 0.4 | 2.1 | 0.766 | 0.7 | 0.2 | 2.5 | 0.652 |
s: Stromal, i: Intratumoral.
Significant p values are in bold