Table 2.
Multivariate survival analysis (Cox regression model) of variables (with and without immune cell markers) predicting outcome in terms of ipsilateral local all recurrences (A) and invasive recurrences (B) in patients treated by breast conserving surgery in pure DCIS.
| Parameters | Hazard ratio (HR) | 95% confidence interval (CI) | p-value | |
|---|---|---|---|---|
| Lower | Upper | |||
| (A) All recurrences | ||||
| Conventional clinicopathological parameters associated with high risk DCIS | ||||
| Patient age | 0.4 | 0.2 | 0.8 | 0.006 |
| DCIS presentationa | 1.5 | 0.9 | 2.4 | 0.111 |
| DCIS size | 1.5 | 1.1 | 2.1 | 0.040 |
| DCIS nuclear Grade | 1.9 | 1.3 | 2.7 | 0.001 |
| Comedo necrosis | 0.6 | 0.4 | 0.9 | 0.049 |
| Margin status | 0.8 | 0.7 | 0.9 | 0.004 |
| TILs density and other clinicopathological parameters | ||||
| Patient age | 0.4 | 0.1 | 0.8 | 0.023 |
| DCIS presentation | 1.5 | 0.9 | 3.8 | 0.395 |
| DCIS size | 0.8 | 0.4 | 1.6 | 0.498 |
| DCIS nuclear Grade | 1.2 | 0.6 | 2.4 | 0.662 |
| Comedo necrosis | 0.6 | 0.3 | 1.3 | 0.196 |
| Margin status | 0.9 | 0.9 | 1.1 | 0.637 |
| Overall TILs density | 7.0 | 2.8 | 1.2 | 0.024 |
| Dense stromal FOXP3+ cells | 1.7 | 0.7 | 0.3 | 0.453 |
| Dense stromal PDL1+ cells | 6.8 | 3.1 | 1.4 | 0.004 |
| Overall TILs density with stromal FOXP3+ and stromal PDL1+ inflammatory cells | ||||
| Overall TILs density | 3.5 | 1.5 | 8.2 | 0.003 |
| Dense stromal FOXP3+ cells | 0.8 | 0.4 | 1.7 | 0.554 |
| Dense stromal PDL1+ cells | 2.9 | 1.4 | 6.1 | 0.005 |
| (B) Invasive recurrence | ||||
|---|---|---|---|---|
| Patient age | 0.5 | 0.2 | 1.3 | 0.156 |
| DCIS presentation | 1.4 | 0.8 | 2.6 | 0.245 |
| DCIS size | 1.8 | 1.1 | 2.4 | 0.013 |
| DCIS nuclear Grade | 1.9 | 1.1 | 3.0 | 0.013 |
| Comedo necrosis | 0.7 | 0.4 | 1.3 | 0.274 |
| Margin status | 0.9 | 0.8 | 1.1 | 0.075 |
| TILs density and other clinicopathological parameters | ||||
| Patient age | 0.7 | 0.2 | 2.4 | 0.527 |
| DCIS presentation | 2.2 | 0.6 | 7.5 | 0.206 |
| DCIS size | 1.7 | 0.6 | 4.7 | 0.301 |
| DCIS nuclear Grade | 2.6 | 0.8 | 8.2 | 0.111 |
| Comedo necrosis | 0.7 | 0.2 | 2.0 | 0.497 |
| Margin status | 0.9 | 0.9 | 1.1 | 0.877 |
| Overall TILs density | 2.1 | 1.2 | 5.5 | 0.029 |
| Dense stromal FOXP3+ cells | 0.3 | 0.1 | 1.4 | 0.143 |
| Dense stromal PDL1+ cells | 1.7 | 0.6 | 5.1 | 0.307 |
| Overall TILs density with stromal FOXP3+ and stromal PDL1+ inflammatory cells | ||||
| Overall TILs density | 2.8 | 1.1 | 7.9 | 0.045 |
| Dense stromal FOXP3+ cells | 0.4 | 0.1 | 1.5 | 0.176 |
| Dense stromal PDL1+ cells | 1.7 | 0.6 | 4.8 | 0.318 |
Significant p values are in bold.
aDCIS presentation refers to the method of DCIS diagnosis either through the mammography screening program or symptomatic presentation.