Table 3.

Substrates scope of carbene/alkyne metathesis terminated with asymmetric C–H functionalization^a.

^aThe reaction was carried out on a 0.2 mmol scale, and Rh₂(S-TFPTTL)₄ (1.0 mol%) was added as a solution in TBME (1.0 mL) via syringe pump in 40 min under inert atmosphere at 40 °C. The yields are given in isolated yields.

^bThe reaction was carried out on a 4.0 mmol scale with 0.5 mol% catalyst loading.

^cAt 60 °C for 12 h.

^dRh₂(S-PTAD)₄ (1.0 mol%) was used as the catalyst.

^eThe reaction was carried out in cyclohexane:TBME = 1:10 at 30 °C.