Table 1.
Clinical characterization of the study cohorts.
| Characteristic | MDD | BI | SCZ | CON | p Value |
|---|---|---|---|---|---|
| Discovery iTRAQ cohort | |||||
| Group size | 12 | 6 | 6 | 14 | – |
| Subgroups | Recurrent depressive disorder (10) | Current episode mixed (3) | Paranoid (4) | – | – |
| Current episode manic (2) | |||||
| Depressive episode (2) | Current episode depression (1) | Undifferentiated (2) | |||
| Age | 46 ± 13.3 | 47.7 ± 11.4 | 36.3 ± 12.7 | 50.2 ± 9.8 | 0.1599 |
| (19.9–69.2) | (33–58) | (23.8–56.7) | (29.4–65.6) | ||
| Sex F/M | 10/2 | 3/3 | 1/5 | 10/4 | – |
| Female | 83.3% | 50.0% | 16.7% | 71.40% | |
| BMI | 25.7 ± 5.8 | 26.4 ± 3.4 | 24.8 ± 1.8 | na | 0.611 |
| Suicide attempters | 33.3% | 16.7% | 16.7% | – | – |
| Elevated albumin ratio | – | 66.7% | 50.0% | – | – |
| MRM cohort | |||||
| Group size | 40 | 11 | 13 | 27 | – |
| Subgroups | Recurrent depressive disorder (30) | Current episode mixed (4) | Paranoid (7) | – | – |
| Current episode manic (3) | |||||
| Depressive episode (10) | Current episode depression (4) | Undifferentiated (6) | |||
| Age | 48 ± 11.3 | 46.6 ± 16.5 | 40.4 ± 14.8 | 49.2 ± 9.6 | 0.0932 |
| (20–69) | (19–74) | (23.8–78.2) | (28.2–65.6) | ||
| Sex F/M | 25/15 | 4/7 | 6/7 | 17/10 | – |
| Female | 62.5% | 36.4% | 46.2% | 63.0% | |
| BMI | 25.4 ± 4.4 | 25.1 ± 4 | 26.4 ± 3.6 | na | 0.6697 |
| Suicide attempters | 27.5% | 27.3% | 15.4% | – | – |
| Elevated albumin ratio | – | 45.5% | 38.5% | – | – |
Given values for age are mean ± SD and ranges in brackets, p values are calculated using Kruskal–Wallis test.
na not available, iTRAQ isobaric tags for relative and absolute quantitation, MRM multiple reaction monitoring.