Skip to main content
. 2020 May 12;10:7849. doi: 10.1038/s41598-020-63900-0

Figure 2.

Figure 2

GW0742 induces HUVEC tubulogenesis in a PPARβ/δ-dependent manner. (a) VEGF-A (25 ng/ml), but not GW0742 (100 nM), significantly increased HUVEC migration in a scratch assay (16 h). Data represent mean (±S.E.M) % migration (n = 3); *p < 0.05 vs. untreated control as determined by one-way repeated measures ANOVA followed by Bonferroni’s post-comparison test. (b) GW0742 (100 nM), but not VEGF-A (25 ng/ml), induced capillary-like tube formation is significantly reduced in the presence of GSK0660 (1 µM) (n = 6). Data represent mean (±S.E.M) number of branches/field; ****p < 0.0001 vs. untreated control; ###p < 0.001; &p < 0.05 vs. GSK0660 control; as determined by two-way repeated measures ANOVA followed by Bonferroni’s post-comparison test. (c) Representative images of capillary-like structures induced by GW0742 (100 nM) and VEGF-A (25 ng/ml) at 16 h in the absence or presence of GSK0660 (1 µM).