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. 2020 May 12;10:7869. doi: 10.1038/s41598-020-64292-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of ERK_1/2 inhibitors on the firing rate of LC neurons. (A) Representative episodes of firing rate recording from LC neurons before (baseline) (left panel) and after 30 mins of drug applications (right panel). The top, middle and bottom traces show the application of U0126, FR180204 and the vehicle (DMSO), respectively. (B-D) Summarized results show the change in the SFR upon U0126 (B), FR180204 (C) and DMSO (D) application. The asterisks indicate a significant difference compared to the control at p < 0.05 (*) or at p < 0.01 (**).