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. 2020 May 12;11:2369. doi: 10.1038/s41467-020-15733-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Intersection of published gene expression signatures composed of genes overexpressed in MLL-rearranged AML and ALL when compared to other MLL-wildtype leukemias. b Relative expression of MBNL1 in non-MLL-rearranged (Kasumi-1, HL60, and K562) cell lines and MLL-rearranged (THP-1, RS4;11, MOLM13 and MV4;11), normalized to CD34+ cord blood expression. Data is from three biological replicates. Bars show mean ± SD. c ChIP-seq tracks of human AML and ALL cell lines expressing different MLL-fusion proteins. ChIP-seq data were obtained from GSE95511 for ML-2, GSE79899 for MV4;11 and THP-1, GSE38403 for RS4;11, and GSE38338 for SEM. d Western blot analysis of MBNL1 levels in MLL-AF9 Tet-off human CD34⁺ cells. Nuclear protein levels were analyzed on day 0, 2, and 6 after doxycycline treatment. Lamin B1 was used as a loading control. Representative western blot shown, two biological replicates performed.