Fig. 3. Enrichment of common variant associations within biologically constrained genes and FMRP target genes across different psychiatric disorders.

Beta coefficient from MAGMA gene-set association model presented for each psychiatric phenotype, which tested association with a a set of genes which display intolerance to loss of function variation (probability of loss of function intolerant [pLI] ≥ 0.9, N_Genes = 3230), b targets of FMRP, N_Genes = 842. Error bars represent the upper and lower bounds of each coefficient relative to its standard error. Blue points indicative of the MAGMA model constructed without covariation for the expression of each gene in the cortex, while pink represents the models covaried for cortical gene expression.