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. 2020 May 12;10:134. doi: 10.1038/s41398-020-0817-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Manhattan plot for each meta-analysis which displays the −log₁₀-transformed P value for association for genes which were tagged by at least one SNP in the respective GWAS. The red line represents the Bonferroni threshold for multiple-testing correction (P < 2.7 × 10⁻⁶). Genes highlighted on each plot were not Bonferroni significant in the individual GWAS but obtained corrected significance in the meta-analysis, with the most significant of these genes labelled for each plot. a Schizophrenia (SZ) and bipolar disorder (BIP) genic meta-analysis, b Schizophrenia and attention-deficit/hyperactivity disorder (ADHD) genic meta-analysis. c Schizophrenia and autism-spectrum disorder (ASD) genic meta-analysis. Manhattan plots for the meta-analyses with MDD, TS, ED and OCD are presented in Supplementary Fig. 1.