Table 1.

Statistical analyses used within the manuscript

	Data structure	Type of test	Comparison	95% confidence interval
Figure 2A	Non-normally distributed	Two-way ANOVA
		Dunett's multiple comparison test	Morphine vs vehicle	0.864 to 1.719
			Morphine vs gefitinib	0.7783 to 2.011
			Morphine vs morphine + gefitinib	–2.349 to –1.117
Figure 2B	Non-normally distributed	Two-way ANOVA
		Dunett's multiple comparison test	Morphine vs vehicle	0.8614 to 1.635
			Morphine vs gefitinib	0.7111 to 1.484
			Morphine vs morphine + gefitinib	–2.034 to –1.223
Figure 2C	Non-normally distributed	Two-way ANOVA
		Dunett's multiple comparison test	Morphine vs vehicle	0.1181 to 1.828
			Morphine vs EGF	0.8573 to 2.567
Figure 3A	Non-normally distributed	Two-way ANOVA
		Dunett's multiple comparison test	Morphine vs sham	–11.35 to –9.522
			Morphine vs gefitinib	–0.9836 to 0.9314
			Morphine vs morphine + gefitinib	–8.873 to –6.958
Figure 3B	Normally distributed	Two-way ANOVA
		Dunett's multiple comparison test	Morphine vs vehicle	–1.497 to 1.603
			Morphine vs EGF-FC	–1.904 to 1.196
			Morphine vs morphine + EGF-FC	–10.45 to –7.348
Figure 4A	Normally distributed	Two-way ANOVA
		Dunett's multiple comparison test	Vehicle vs imatinib	–1.891 to 2.498
			Vehicle vs EGF	6.313 to 10.07
			Vehicle vs EGF+ imatinib	–6913 to 3.697
Figure 4B	Normally distributed	Two-way ANOVA
		Dunett's multiple comparison test	Vehicle vs imatinib	–1.515 to 1.977
			Vehicle vs EGF	–1.367 to 2.126
			Vehicle vs EGF+ imatinib	–1.732 to 1.761
Figure 4C	Normally distributed	Two-way ANOVA
		Dunett's multiple comparison test	Vehicle vs gefitinib	–1.408 to 2.104
			Vehicle vs PDGF	4.401 to 7.913
			Vehicle vs PDGF+ gefitinib	–0.1661 to 3.346
Figure 4D	Normally distributed	Two-way ANOVA
		Dunett's multiple comparison test	Vehicle vs gefitinib	–0.921 to 1.743
			Vehicle vs PDGF	–0.9921 to 1.536
			Vehicle vs PDGF+ gefitinib	–0.606 to 2.058