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. 2020 May 6;10:615. doi: 10.3389/fonc.2020.00615

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Copyright © 2020 Li, Xiong, Xiao, Yang, Yang, Tang, Zhang and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LINC02195 expression was positively correlated with the infiltration of CD8⁺ and CD4⁺ T cells in the TME. (A) Representative image of multiplex staining (CD8, CD4, PD-1, pan-keratin, and DAPI) in human HNSCC specimens (low LINC02195 expression vs. high LINC02195 expression). Scale bar, 100 μm. (B,C) Pearson's correlation coefficient between the histoscore of LINC02195 and the number of CD8⁺ or CD4⁺ cells in the human HNSCC TMA. (D) Hierarchical clustering analysis of LINC02195, CD4, and CD8 expression in human HNSCC samples (n = 59).