Table 1.
CAR T cell trials in myeloid malignancies currently recruiting.
| Disease | Interventions | Identifier ID | Phase | Location |
|---|---|---|---|---|
| AML | CD123/CLL1 CAR T cells | NCT03631576 | II/III | Fujian Medical University Union Hospital, China |
| CLL-1, CD33 and/or CD123 CAR T cells | NCT04010877 | I/II | Shenzhen Geno-Immune Medical Institute, China | |
| CD123 CAR T cells | NCT03796390 | I | Hebei Yanda Ludaopei Hospital, China | |
| CD123 CAR T cells | NCT03585517 | I | Xian Lu, China | |
| Muc1/CLL1/CD33/CD38/CD56/CD123 CAR T cells | NCT03222674 | I/II | Zhujiang Hospital of Southern Medical University, Yunnan Cancer Hospital, Shenzhen Geno-immune Medical Institute, China | |
| CD38/CD33/CD56/CD123/CD117 /CD133/CD34/Mucl CAR T cells | NCT03473457 | N/A | Southern Medical University Zhujiang Hospital, China | |
| CD123 CAR T cells expressing EGFRt | I | Fengtai District, China | ||
| CD44v6 CAR T cells | NCT04097301 | I/II | IRCCS San Raffaele, IRCCS Ospedale Pediatrico Bambino Gesù, Italy | |
| CD33 CAR T cells | NCT03971799 | I/II | The Children's Hospital of Philadelphia, USA | |
| Universal CD123 CAR T cells | NCT03190278 | I | H. Lee Moffitt Cancer Center, Dana-Farber Cancer Institute, Weill Medical College of Cornell University, MD Anderson Cancer Center, USA | |
| CD123 CAR T cells | NCT04014881 | I | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China | |
| CD123 CAR T cells | NCT03556982 | I/II | 307 Hospital of PLA, China | |
| CD123 CAR T cells expressing EGFRt | NCT02159495 | I | City of Hope Medical Center, USA | |
| CD123 CAR T cells | NCT03766126 | I | University of Pennsylvania, USA | |
| AML/MDS | CD33/CD38/CD56/CD117/CD123/CD34 /Muc1 CAR T cells + Eps8 or WT1 peptide specific dendritic cell | NCT03291444 | I | Zhujiang Hospital, Southern Medical University, China |
| NKG2D CAR T cells | NCT03018405 | I/II | USA and Belgium | |
| AML/MDS/MPN | CD123-CD33 cCAR T cells | NCT04156256 | I | Chengdu Military General Hospital, Peking University Shenzhen Hospital, China |
| CLL1-CD33 cCAR T cells | NCT03795779 | I | The General Hospital of Western Theater Command, Peking University Shenzhen Hospital, China | |
| CML | IL-1RAP CAR T cells | NCT02842320 | N/A | Hôpital Nord Franche-Comté, Centre Hospitalier Régional Universitaire de Besançon, CHU de Dijon, CHI de Haute-Saône, France |
Information available from www.clinicaltrials.gov using search term “CAR” and “AML” or “MDS” or “MPN” or “CML” in January 2020. AML: acute myeloid leukemia; CAR, chimeric antigen receptor; CML, chronic myeloid leukemia; MDS, myelodysplastic syndrome; MPN, myeloproliferative neoplasms; EGFRt, epidermal growth factor receptor truncated.