TABLE 2.

Summary of testing of ADAM10 selective inhibitors with various cell-based ADAM10 and synthetic substrates.

Target	Cell line	Glycosylation type	Position	[C] tested, μM	CID3117694, %inhibition (IC50, μM)	GI254023X, %inhibition
TNFα non-glycosylateda	N/A	None	N/A	0.01–100	18 (>100)	100
TNFα glycosylateda	N/A	Gal-GalNAc	S4	0.01–100	100 (1.1)	100
HER2a	BT474	GlcNAc	Multiple (Yuan et al., 2003)	10	0	100
CXCL16a	A549	Gal-GalNAc	Multiple (Abel et al., 2004)	10	80	100
Syndecan-4a	A549	Heparan Sulfate	S39, S61, S63 (Bernfield et al., 1992)	10	0	100

NT, not tested. ^aMadoux et al. (2016).