TABLE 3.
Results of Pubmed and UniProt database searches for information on glycosylation of ADAM10 cognate substrates available for cancer and rheumatoid arthritis.
| Accession # | Substrate | Cleavage site | Known glycosylation position | Closest distance from scissile bond, #residues | Glyco type in normalcy | Role in cancer | Glyco type in cancer | Role in RA | Glyco type in RA |
| P35070 | Pro-betacellulin | CVVA31/32DGN*S | N34 | 3 | N-linked (GlcNAc) (Watanabe et al., 1994; UniProt, 2019) | Feldinger et al., 2014 | Not found | Harada et al., 2015 | Not found |
| P01375 | pro-TNFa | LAQA76/77VRSS | S80 | 4 | O-linked (GalNAc) (Goth et al., 2015) | Kondo et al., 1994; Janes et al., 2006; Miyazawa et al., 2008; Malekshah et al., 2012 | O-linked (GalNAc) (Takakura-Yamamoto et al., 1996) | Jimi et al., 2019 | Not found |
| P02786 | Transferrin receptor | TECER100∼ LAGT*E | T104, N251, N317, N727 | 4 | O-linked (GalNAc) (Do and Cummings, 1992; Hayes et al., 1992; Lawrence et al., 1999) | Shen et al., 2018 | O-linked (GalNAc) (Rutledge and Enns, 1996) | Pavai et al., 2007 | Not found |
| A0N0L5 | IL6-R | T*SLPVQ357∼DS*S*SV | S359, S360, T353, N55, N93, N221, N350 | 2 | O-linked (GalNAc) O-linked (HexNAc) N-linked (GlcNAc) Cole et al., 1999; Goth et al., 2015 | Deng et al., 2019; He et al., 2019; Weng et al., 2019; Yousefi et al., 2019 | Not found | Ahmed et al., 2017 | Not found |
| P05067 | APP | *YEVHHQK687∼LVFFA | N542, N571, T633, T651, T652, S656, T659, T663, S663, S667, Y681 | 6 | N-linked (GlcNAc) (Halim et al., 2011; Brinkmalm et al., 2012) | Wozniak and Ludwig, 2018; Wu et al., 2020 | Not found | Kuroda et al., 2019 | Not found |
| O14944 | Pro-epiregulin | DNPR59/60VAQV | N47 | 12 | N-linked (GlcNAc) (UniProt, 2020a) | Wang et al., 2019 | Not found | Harada et al., 2015 | Not found |
| Q99075 | pro-HB-EGF | RKVR62/63DLQE | T37, S38, T44, T47, T75, T85 | 13 | O-linked (GalNAc) (Halim et al., 2011, 2012) | Branco et al., 2019; Gelfo et al., 2019; Moore et al., 2019; Finn et al., 2020 | O-linked (GalNAc) Davis-Fleische et al., 2001 | Kuo et al., 2019 | Not found |
| P01135 | pro-TGFa | VAAA39/40VVSH | N25 | 14 | N-linked (GlcNAc) UniProt, 2020b | Yu et al., 2018; Poteet et al., 2019 | Not found | Hallbeck et al., 2005 | Not found |
| P04626 | EGFR2 | AEQR646/647ASPL | N68, N124, N187, N259, N530, N571, N629 | 17 | N-linked (GlcNAc) (Franklin et al., 2004; Bostrom et al., 2009; Eigenbrot et al., 2010) | Landi and Cappuzzo, 2013; Ingthorsson et al., 2016; Cirstea et al., 2017 | Not found | Hallbeck et al., 2005; Shchetynsky et al., 2017 | Not found |
| P15514 | pro-Amphiregulin | IVDD100/101SVRV; | N30, N113, N119 | 18 | N-linked (GlcNAc) (UniProt, 2020d) | Oliveras-Ferraros et al., 2012; Rexer et al., 2013 | Not found | Nakamura et al., 2006; Yamane et al., 2008; Liu et al., 2014 | Not found |
| P06734 | CD23 | EERA61∼RN*VSQVSKN | N63 | 2 | N-linked (GlcNAc) UniProt, 2020c | Kwon et al., 2012 | Not found | Rambert et al., 2009; Kuzin et al., 2016 | Not found |