TABLE 1.

List of ncRNAs with a known or potential function (asterisk) in neuronal physiology and disease.

Name	Classification	Proximal/overlapping coding gene	Molecular function	Biological function	Disease	References
RMST	lincRNA	N/A	Decoy for transcription factor	ESC self-renewal and inhibition of neural differentiation	N/A	Ng et al., 2013
Evf2	NAT	Dlx6	Scaffold RNA for transcription factors and chromatin remodeling	Neuronal differentiation and development	N/A	Bond et al., 2009
Pnky	Divergent	Pou3f2	Decoy for splicing factors	Neural Stem Cell self-renewal	N/A	Ramos et al., 2015
Cyrano	lincRNA	N/A	target RNA-directed miRNA degradation	ESC self-renewal	N/A	Kleaveland et al., 2018
Lhx1os	Divergent	Lhx1	Unknown	Neuronal Differentiation	ALS	Biscarini et al., 2018
LncMN-1	Divergent	Pcdh10	Unknown	Neuronal Differentiation	ALS	Biscarini et al., 2018
BC200	Intronic	Epcam-DT	Scaffold RNA for translation factors	Regulates translation at synapsis	AD	Muslimov et al., 1998; Wang et al., 2002; Zalfa et al., 2003
MALAT1	lincRNA	N/A	Decoy for splicing factors, paraspeckle	Neuronal Stress Response	ALS, HD, FTD, AD	Ji et al., 2003; Bernard et al., 2010
BDNF-AS	NAT	Bdnf	Scaffold RNA	Synaptogenesis	HD	Lipovich et al., 2012; Modarresi et al., 2012
SMN-AS1	NAT	Smn	Scaffold RNA	Neuronal Differentiation	SMA	d’Ydewalle et al., 2017
SORL1-AS	NAT	Sorl1	Scaffold RNA	Unknown	AD	Ciarlo et al., 2013
BACE1-AS	NAT	Bace1	RNA-RNA interaction for miRNA masking	Beta amyloid formation	AD	Faghihi et al., 2008; Faghihi et al., 2010
UCHL1-AS	NAT	Uchl1	RNA-RNA interaction through SINEUP	Neuronal Stress Response	AD, PD	Carrieri et al., 2015
NEAT1	lincRNA	N/A	Scaffold RNA for splicing factors, Paraspeckle	Neuronal Stress Response	ALS, HD, FTD, AD	Nishimoto et al., 2013; An et al., 2018
C9ORF72-AS	NAT	C9ORF72	RNA foci	Unknown	ALS	DeJesus-Hernandez et al., 2011; Cooper-Knock et al., 2015b
PINK1-AS	NAT	Pink1	RNA-RNA interaction in cis on Pink1	Mithocondrial function	PD	Scheele et al., 2007
FMR4	NAT	Fmr1	Scaffold RNA in trans for chromatin remodeling	Neural precursor proliferation	FXS, FXTAS	Khalil et al., 2008; Peschansky et al., 2016
HTT-AS	NAT	Htt	Decoy for transcription factor in cis on HTT	Unknown	HD	Chung et al., 2011
ATXN8-OS	NAT	Sca8	RNA foci	Unknown	SCA	Moseley et al., 2006
SCAANT1	NAT	Sca7	Decoy for transcription factor in cis on Sca7	Unknown	SCA	Sopher et al., 2011
CDR1-AS	circRNA	CDR1	miRNA sponge	Synaptic transmission	AD, PD	Hansen et al., 2013; Memczak et al., 2013; Piwecka et al., 2017
circRims2	circRNA	Rims2	Unknown	Unknown	N/A	Rybak-Wolf et al., 2015
circDym	circRNA	Dym	miRNA sponge	Microglial activation	Depressive-like behavior	Rybak-Wolf et al., 2015; Zhang et al., 2018b
circPldxnd1	circRNA	Pldxnd1	Unknown	Unknown	N/A	Rybak-Wolf et al., 2015
circStau2	circRNA	Stau2	Unknown	Unknown	N/A	Rybak-Wolf et al., 2015
circHomer1_a	circRNA	Homer1	Unknown	Homeostatic synaptic plasticity*	N/A	You et al., 2015
mmu_circRNA_017963	circRNA	Tbc1d30	miRNA sponge*	Apoptotic process, transport and RNA splicing, synaptic functions*	AD	Huang et al., 2018
circDLGAP4	circRNA	Dlgap4	miRNA sponge	Cell viability, apoptosis, mitochondrial damage, and autophagy	PD	Feng et al., 2019

N/A is for “Not Applicable.”