Table 1.

Characteristics of included randomized clinical trials.

Study	Design	No. of patients	Clinical settings	Intervention		Outcome measurement	Jadad score
				Treatment group	Comparison group
Acevedo et al., 2009*	Single center	24	Cirrhotic patients with septic shock	Terlipressin	Alpha-adrenergic drugs	Hospital mortality ICU mortality	1
Albanese et al., 2005	Single center	20	Septic shock	Terlipressin	NE	Hospital mortality	2
Barzegar et al., 2016	Single center	30	Septic shock	Vasopressin plus NE	NE	28-day mortality ICU mortality	4
Capoletto et al., 2017	NA	250	Cancer patients with septic shock	Vasopressin	NE	28-day mortality 90-day mortality	3
Chen et al., 2017	Single center	57	Septic shock patients with ARDS	Terlipressin plus NE	NE	28-day mortality	3
Choudhury et al., 2017	Single center	84	Liver cirrhosis with septic shock	Terlipressin	NE	28-day mortality 48-h mortality	4
Clem et al., 2016*	Single center	82	Septic shock	Vasopressin plus NE	NE	28-day mortality	1
Fonseca-Ruiz et al., 2013	Single center	30	Septic shock	Vasopressin plus NE	NE	28-day mortality	4
Gordon et al., 2016	Multicenter	409	Septic shock	Vasopressin	NE	28-day mortality Hospital mortality ICU mortality	5
Han et al., 2012	Multicenter	139	Septic shock	Pituitrin	Dopamine or NE	28-day mortality	1
Hua et al., 2013	Single center	32	Septic shock patients with ARDS	Terlipressin	Dopamine	28-day mortality	2
Laterre et al., 2019	Multicenter	828	Septic shock	Selepressin	Placebo	30-day mortality 180-day mortality	5
Lauzier et al., 2006	Multicenter	23	Septic shock	AVP	NE	ICU mortality	3
Liu et al., 2018	Multicenter	526	Septic shock	Terlipressin	NE	28-day mortality	5
Morelli et al., 2008 a	Single center	59	Septic shock	Terlipressin plus NE Terlipressin plus NE and dobutamine	NE	ICU mortality	3
Morelli et al., 2009 a	Single center	45	Septic shock	Terlipressin plus NE AVP plus NE	NE	ICU mortality	3
Oliveira et al., 2014*	Single center	387	Septic shock	Vasopressin plus NE	NE	28-day mortality	3
Prakash et al., 2017*	Single center	184	Cirrhosis with septic shock.	Terlipressin plus NE	NE	30-day mortality	1
Russell et al., 2008	Multicenter	799	Septic shock	Vasopressin	NE	28-day mortality 90-day mortality	5
Russell et al., 2017	Multicenter	48	Septic shock	Selepressin	Placebo	28-day mortality	5
Svoboda et al., 2012	Single center	30	Septic shock	Terlipressin plus NE	NE	28-day mortality	3
Xiao et al., 2016	Single center	32	Septic shock	Terlipressin plus NE	NE	7-day mortality 24-h mortality	3
Zambolim et al., 2014*	Single center	107	Septic shock and cancer	Vasopressin	NE	28-day mortality	1

NE, norepinephrine; AVP, arginine vasopressin; ICU, intensive care unit; ARDS, acute respiratory distress syndrome.

NA, not available from article or author.

*Published in abstract only.

^aMorelli et al., 2008 and Morelli et al., 2009 have compared three arms.