Table 2.
Logistic and Cox regression to predict outcomes after 10 years for FPe and covariates.
| Endpoint variable and regression model | Risk ratio for FPe (95% CI) | P value |
|---|---|---|
| Combined endpoint of either death, cardiovascular hospitalization or occurrence of HF signs/symptoms | OR | |
| Unadjusted | 1.61 [1.12 – 2.31] | 0.010 |
| Adjusted for age and sex | 1.41 [0.97 – 2.06] | 0.072 |
| Adjusted for age, betablocker and anticoagulant therapy | 1.13 [0.76 – 1.67] | 0.550 |
| All-cause mortality | HR | |
| Unadjusted | 3.13 [2.05 – 4.79] | <0.001 |
| Adjusted for age and sex | 1.90 [1.21 – 2.99] | 0.005 |
| Adjusted for age and sex, heart rate and renal impairment | 1.98 [1.25 – 3.14] | 0.004 |
| Death or cardiovascular hospitalization | HR | |
| Unadjusted | 2.08 [1.55 – 2.79] | <0.001 |
| Adjusted for age and sex | 1.61 [1.18 – 2.21] | 0.003 |
| Adjusted for age, sex, renal impairment and betablocker therapy | 1.43 [1.04 – 1.97] | 0.026 |
| Occurrence of HF signs/symptoms | OR | |
| Unadjusted | 1.60 [1.14 – 2.26] | 0.007 |
| Adjusted for age and sex | 1.47 [1.03 – 2.10] | 0.034 |
| Adjusted for age, sex, coronary artery disease, pulse pressure and heart rate | 1.22 [0.84 – 1.77] | 0.310 |
FPe = asymptomatic patients that fulfill HFA/ESC criteria for HFpEF (elevated left ventricular filling pressure); HF = heart failure.