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. 2020 May 6;11:782. doi: 10.3389/fimmu.2020.00782

FIGURE 2.

FIGURE 2

Phenotypic characterization of thymic and peripheral regulatory cells. (A) Percentages of indicated cell populations among total CD4 + T cells in healthy individuals (blue) or in myasthenic patients (orange) in the thymus (left panel) or in PBMCs (right panel). Mean fluorescent intensities of CD25 (B), FoxP3 (C), CD127 (D), CD31 (E) in healthy individuals (blue) or in myasthenic patients (orange) in the 3 subsets defined by the combination of CD45RA and CD25 in thymus (left panel) or in PBMCs (right panel). Statistical test: two-tailed Mann-Whitney (∗p ≤ 0.05; ∗∗p ≤ 0.01; and ∗∗∗p ≤ 0.005, gray star corresponds to p < 0.1). (F) Statistical summary of the data shown in (B–E). Colorized bubbles correspond to significant differences. Size is proportional to the statistical significance and color represents fold change between mean values of control individuals and MG patients (green, lower value in MG; red, higher value in MG).