TABLE 2.

Location of consensus mutations.

Mutation	Domain	Secondary structure motif	Relative position	Distance to the T1Cu Site (Å)	Distance to the T2/T3Cu cluster (Å)
I25V	D1	β-sheet	Buried	23.7	15.8
V27A	D1	β-sheet	Buried	25.7	15.6
S33G	D1	Loop	Surface	23.7	14.7
D50N	D1	β-sheet	Partially buried	26.1	18.0
M52L	D1	Loop	Partially buried	24.2	17.6
A92S	D1	β-sheet	Surface	31.8	21.2
D142E	D2	Loop	Surface	29.3	19.7
T179G	D2	Loop	Surface	29.2	29.2
Y208F	D2	β-sheet	Close to Asp205 that interacts with phenols	14.3	13.9
L217M	D2	β-sheet	Partially buried	24.5	22.2
V219I	D2	β-sheet	Buried	23.2	19.1
Q230L	D2	β-sheet	Surface	24.7	23.1
A240G	D2	β-sheet	Close to T2/T3 and His-Cys-His pathway	11.4	5.3
D250N	D2	Loop	Surface	38.0	34.4
N268G	D2	Loop	Surface	23.1	27.0
T306P	D2	Loop	Buried	20.3	25.8
M327L	D3	β-sheet	Partially buried	11.9	13.1
Y421R	D3	Loop	Surface	20.1	13.7
F454W	D3	α-helix	Surface, at the vicinity of the binding pocket	7.3	11.1
M464F	D3	β-sheet	Buried	10.7	17.1