Table 5.

Gene set enrichment analysis of PD modules.

ID	# Gene	# PD egene	P-value	FDR	GSEA inferred module function	PD-relevant evidence
PD36	39	20	2.94E-23	1.50E-21	GPCR ligand binding	Martin et al., 2005
PD41	33	17	5.62E-20	9.55E-19	Retinoic acid biosynthesis	Jacobs et al., 2007; Esteves et al., 2015,
PD42	32	13	7.47E-14	9.52E-13	GPI-anchor biosynthesis, ER/Golgi trafficking, Membrane lipid biosynthesis	Wang et al., 2014, Abeliovich and Gitler, 2016
PD12	126	19	5.45E-11	5.56E-10	Endocytosis, Immune response	Mosley et al., 2012; Abeliovich and Gitler, 2016
PD20	80	13	2.57E-08	2.18E-07	Immune response, Integrin cell surface	Wu and Reddy, 2012
PD37	38	9	1.28E-07	9.35E-07	Potassium channels, Glycogen metabolism	Chen et al., 2018
PD44	30	7	3.75E-06	2.12E-05	Hemoglobin complex	Freed and Chakrabarti, 2016
PD10	135	13	1.18E-05	6.00E-05	Oxidoreductase activity	Parker et al., 2008
PD34	42	7	3.94E-05	1.82E-04	Glycosaminoglycans biosynthesis	Lehri-Boufala et al., 2015
PD45	29	5	4.43E-04	1.74E-03	Immune response, Natural killer cell mediated immunity	Mihara et al., 2008
PD35	42	5	2.49E-03	9.08E-03	Lysosome, Sphingolipic metabolism	Dehay et al., 2013, Lin et al., 2019
PD46	29	4	3.96E-03	1.34E-02	WNT signaling pathway, Dopaminergic neuron differentiation	Arenas, 2014

# Gene, number of genes in a module; # PD egene, number of egene regulated by PD susceptibility variants in a module.