Table 4.

The detail information of three pathways mainly involved in lipid metabolism.

No.	Pathway	Targets	Count	Relevant targets	p-Value	Benjamini	Category	References
1	PPAR signaling pathway	PPARα, APOA1, CD36, OLR1, PPARG	5	RXR, LXRα, CYP7A1, PPARβ, PPARγ, APOAV	6.35E-04	0.005524	Lipid metabolism	(Hansjörg et al., 1993; Wu and Xu, 2016)
2	SREBP control of lipid synthesis	SREBF1, LDLR, SREBF2	3	SCAP, SRE1, HMGCS	0.008613	0.306643	Lipid metabolism	(Eberle et al., 2004; Giudetti et al., 2013)
3	Nuclear receptors in lipid metabolism and toxicity	PPARα, CYP2C9, PPARG, ABCA1	4	LXRα, CYP7A1, CYP27B1, ABCG1, ABCG5	0.024963	0.414386	Lipid metabolism	(Beaven and Tontonoz, 2006)