Table 2.
Univariate analysis of the training cohort.
| Variables | 3-year OS (%) | 5-year OS (%) | HR (95% CI) | P value |
|---|---|---|---|---|
| Age, years | 86.0 | 78.8 | 1.023 (1.021–1.026) | <0.001 |
| Gender | ||||
| Male | 84.7 | 76.7 | 1 (Ref) | – |
| Female | 87.6 | 81.1 | 0.763 (0.728–0.799) | <0.001 |
| Histological grade | ||||
| Grade I | 91.9 | 86.7 | 1 (Ref) | – |
| Grade II | 87.7 | 80.3 | 1.399 (1.271–1.539) | <0.001 |
| Grade III | 77.1 | 69.6 | 2.104 (1.896–2.334) | <0.001 |
| Grade IV | 70.9 | 64.2 | 2.590 (2.167–3.095) | <0.001 |
| AJCC 8th T stage | ||||
| T1 | 94.5 | 90.9 | 1 (Ref) | – |
| T2 | 93.8 | 89.7 | 1.246 (1.099–1.412) | <0.001 |
| T3 | 85.9 | 78.0 | 2.314 (2.081–2.573) | <0.001 |
| T4a | 72.1 | 61.4 | 4.278 (3.782–4.840) | <0.001 |
| T4b | 63.2 | 51.8 | 5.696 (5.021–6.462) | <0.001 |
| AJCC 8th N stage | ||||
| N0 | 91.5 | 86.2 | 1 (Ref) | – |
| N1a | 85.8 | 78.0 | 1.509 (1.403–1.623) | <0.001 |
| N1b | 83.3 | 73.3 | 1.884 (1.723–1.974) | <0.001 |
| N2a | 75.2 | 64.1 | 2.636 (2.454–2.832) | <0.001 |
| N2b | 59.7 | 47.1 | 4.330 (4.036–4.645) | <0.001 |
| Positive lymph nodes | 86.0 | 78.8 | 1.096 (1.092–1.100) | <0.001 |
| Tumor size, mm | 86.0 | 78.8 | 1.003 (1.003–1.004) | <0.001 |
| Retrieved lymph nodes | 86.0 | 78.8 | 0.989 (0.986–0.991) | <0.001 |
AJCC, American Joint Committee on Cancer; CI, confidence interval; HR, hazard ratio; OS, overall survival; Ref, reference.