Table 1.

Study Design to Compare AAVhu68 Administration via Intra-cisterna Magna (ICM) Injection or Lumbar Puncture (LP) in Adult and Juvenile Rhesus Macaques

Age	Route of Administration	Dose Volume	Number of Animals
Adult (3–6 years)	ICM	1 mL	3
	LP	5 mL	4
Juvenile (12–14 months)	ICM	1 mL	3
	LP	5 mL	2

Macaques were administered 3 × 10¹³ GC of an AAVhu68 vector expressing a human SMN transgene. The study duration was 28 days.