Figure 2.

Genome-wide Transcriptome Analysis of modified Capan-1 cells

(A and B) Volcano plots showing the gene expression changes of Capan-1 luciferase versus Capan-1 parental (A) and Capan-1 SMAD4-luciferase versus Capan-1 luciferase (B). Highlighted in red are genes with a fold change of 2 and p < 0.05. (C) Gene set enrichment analyses (GSEA) of interferon-α and inflammatory response in Capan-1 luciferase versus parental cells. (D) GSEA of epithelial-to-mesenchymal transition and apoptosis signature in Capan-1 SMAD4 versus Capan-1 luciferase cells. ES, enrichment score; NES, normalized enrichment score; FDR, false discovery rate.