Fig. 2.

Molecular exposure responses in the lungs across the five data modalities. (A) Numbers of differentially expressed/abundant mRNAs, proteins, metabolites, miRNAs, and lipids per group relative to Sham exposure (FDR-adjusted p value <0.05). (B) Evaluation of biological impact on lung tissue by using a causal network enrichment approach based on transcriptomics data. RBIFs are represented for each group versus Sham comparisons. See Supplementary Fig. 1 for individual causal network responses [Supplementary File 1]. (C) Correlation between gene and protein expression/abundance fold changes for 3R4F versus Sham at the 3-, 4-, and 6-month time points. Dots indicate the significance of differential expression: red, both protein and mRNA; blue, mRNA only; green, protein only; grey, not significant. Blue line represents fit from linear model; R2, coefficients of determination. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)