Table 1.
The characteristics of included studies in this meta‐analysis
| First author (year) | Country | Ethnicity | Type of disease | Sample size | Genotype distribution | p value for HWE | NOS score | |
|---|---|---|---|---|---|---|---|---|
| Cases | Controls | |||||||
| rs1799983 G/T | GG/GT/TT | |||||||
| Du (2014) | China | East Asian | Aneurysmal subarachnoid hemorrhage | 60/60 | 27/19/14 | 39/16/5 | .097 | 7 |
| Khurara (2004) | USA | Caucasian | Aneurysmal subarachnoid hemorrhage | 51/90 | 20/25/6 | 20/55/15 | .032 | 7 |
| Kim (2011) | Korea | East Asian | Intracranial aneurysms | 149/121 | 125/24/0 | 98/23/0 | .248 | 8 |
| Konar (2019) | India | Mixed | Aneurysmal subarachnoid hemorrhage | 100/100 | 71/23/6 | 76/23/1 | .607 | 7 |
| Koshy (2008) | India | Mixed | Aneurysmal subarachnoid hemorrhage | 122/224 | 85/35/2 | 159/61/4 | .501 | 8 |
| Krex (2006) | Germany | Caucasian | Intracranial aneurysms | 142/190 | 64/67/11 | 96/76/18 | .602 | 7 |
| Krischek (2006) | Japan | East Asian | Intracranial aneurysms | 405/176 | 349/50/6 | 145/23/8 | <.001 | 8 |
| Liu (2013) | China | East Asian | Intracranial aneurysms | 82/82 | 49/25/8 | 36/38/8 | .656 | 8 |
| Ozum (2008) | Turkey | Caucasian | Aneurysmal subarachnoid hemorrhage | 53/60 | 26/23/4 | 34/22/4 | .863 | 8 |
| Staalsø (2014) | Denmark | Caucasian | Aneurysmal subarachnoid hemorrhage | 331/498 | 151/153/27 | 233/216/49 | .918 | 8 |
| Xu (2009) | China | East Asian | Aneurysmal subarachnoid hemorrhage | 58/67 | 27/17/14 | 45/15/7 | .005 | 7 |
| Zhao (2008) | China | East Asian | Hypertensive intracerebral hemorrhage | 70/112 | 53/15/2 | 105/7/0 | .732 | 7 |
| Zhe (2019) | China | East Asian | Aneurysmal subarachnoid hemorrhage | 169/156 | 90/50/29 | 106/38/12 | .003 | 8 |
| rs2070744 T/C | TT/TC/CC | |||||||
| Akagawa (2005 a) | Japan | East Asian | Intracranial aneurysms | 220/214 | 176/41/3 | 179/34/1 | .648 | 8 |
| Akagawa (2005 b) | Korea | East Asian | Intracranial aneurysms | 191/191 | 144/46/1 | 149/41/1 | .304 | 8 |
| Deng (2018) | China | East Asian | Aneurysmal subarachnoid hemorrhage | 71/142 | 70/1/0 | 130/11/1 | .177 | 7 |
| Khurara (2003) | USA | Caucasian | Aneurysmal subarachnoid hemorrhage | 52/90 | 12/35/5 | 28/46/16 | .699 | 7 |
| Kim (2011) | Korea | East Asian | Intracranial aneurysms | 149/121 | 122/24/3 | 99/22/0 | .271 | 8 |
| Konar (2019) | India | Mixed | Aneurysmal subarachnoid hemorrhage | 100/100 | 71/23/6 | 76/23/1 | .607 | 7 |
| Koshy (2008) | India | Mixed | Aneurysmal subarachnoid hemorrhage | 122/224 | 68/51/3 | 136/81/7 | .219 | 8 |
| Krex (2006) | USA | Caucasian | Intracranial aneurysms | 135/184 | 48/60/27 | 71/86/27 | .908 | 7 |
| Krischek (2006) | Japan | East Asian | Intracranial aneurysms | 405/176 | 326/72/7 | 145/23/8 | <.001 | 8 |
| Liu (2013) | China | East Asian | Intracranial aneurysms | 82/82 | 59/19/4 | 69/12/1 | .569 | 8 |
| Song (2006) | Korea | East Asian | Aneurysmal subarachnoid hemorrhage | 132/113 | 106/26/0 | 100/13/0 | .516 | 7 |
| Staalsø (2014) | Denmark | Caucasian | Aneurysmal subarachnoid hemorrhage | 331/498 | 145/147/39 | 197/233/68 | .946 | 8 |
| Zhe (2019) | China | East Asian | Aneurysmal subarachnoid hemorrhage | 169/156 | 82/60/27 | 95/47/14 | .029 | 8 |
| rs869109213 VNTR | 4b4b/4b4a/4a4a | |||||||
| Bi (2010) | China | East Asian | Aneurysmal subarachnoid hemorrhage | 80/107 | 59/18/3 | 91/16/1 | .753 | 8 |
| Fang (2011) | China | East Asian | Hypertensive intracerebral hemorrhage | 62/236 | 52/10/0 | 187/48/1 | .257 | 7 |
| Khurara (2004) | USA | Caucasian | Aneurysmal subarachnoid hemorrhage | 51/90 | 25/25/1 | 70/16/4 | .029 | 7 |
| Kim (2011) | Korea | East Asian | Intracranial aneurysms | 149/121 | 122/24/3 | 96/25/0 | .205 | 8 |
| Konar (2019) | India | Mixed | Aneurysmal subarachnoid hemorrhage | 100/100 | 65/30/5 | 72/25/3 | .648 | 7 |
| Koshy (2008) | India | Mixed | Aneurysmal subarachnoid hemorrhage | 122/224 | 77/40/5 | 143/77/4 | .077 | 8 |
| Krex (2006) | Germany | Caucasian | Intracranial aneurysms | 142/189 | 98/41/3 | 126/55/8 | .525 | 7 |
| Krischek (2006) | Japan | East Asian | Intracranial aneurysms | 405/176 | 325/70/10 | 143/30/3 | .341 | 8 |
| Staalsø (2014) | Denmark | Caucasian | Aneurysmal subarachnoid hemorrhage | 332/498 | 254/71/7 | 344/145/9 | .155 | 8 |
Abbreviations: HWE, Hardy–Weinberg equilibrium; NA, not available; NOS, Newcastle–ottawa scale.