Fig. 2.

The profiles of angiogenesis-related proteins in RPE-derived exosomes. Each type of exosome was collected from supernatants of ARPE-19 cells that were incubated without (Ex-CTL) or with TNF-α (Ex-TNF), TGF-β2 (Ex-TGF) or co-stimulation (Ex-CO) for 3 days. Equal amounts of total protein from each sample were subjected to human angiogenesis array. Spot images of arrays at the same exposure time and the mean pixel density are shown in the graph. The numbers on the images denote 1, coagulation factor ΙΙΙ; 2, Serpin E1; 3, MMP-9; 4, DPPIV; 5, Activin A; 6, TIMP-1; 7, Pentraxin 3; 8, Thrombospondin-1; 9, IGFBP-3; 10, IL-8; 11, VEGF; and 12, MCP-1.