Fig. 7.

Lipids secreted by stressed PBMCs alleviate symptoms of DNFB-induced CH. (a) Hematoxylin/eosin-stained ears 24 h after DNFB elicitation. Representative micrographs of n = 5 mice per treatment condition are shown. ac, auricular cartilage; c, cornified epidermis; d, dermis; epi, epidermis. Scale bar, 200 µm. (b) Increase in ear thickness determined by micrometric assessment 24 h post DNFB re-challenge. * denotes p<.05 versus vehicle. N = 5 mice per group. One-tailed student's t-test for paired samples was performed to compare PBMCsec versus vehicle. (c) Number of stromal cells per field. * indicates p<.05 versus vehicle. N = 5 mice per group. One-tailed student's t-test for paired samples was performed to compare PBMCsec versus vehicle.