Table 1.
Antiviral and cytotoxic effects of tested compounds against HAdV-19 determined by MTT assay.
|
EC50 (µM) |
CC50 (µM) |
SI |
||||
|---|---|---|---|---|---|---|
| Compounds | MT-2 | A549 | MT-2 | A549 | MT-2 | A549 |
| CDV | 62 ± 26 | 4.2 ± 1.1 | >100 | >1.6 | >24 | |
| ddC | 2.6 ± 0.4 | 0.35 ± 0.04 | >100 | >38 | >286 | |
| FdT | 1.8 ± 0.2 | 0.03 ± 0.01 | 36 ± 5 | 7.6 ± 4.2 | 20 | >253 |
| RBV | >18 | >53 | 18 ± 1 | 53 ± 21 | NA | |
| GCV | 60 ± 7 | 54 ± 27 | >100 | >1.7 | >1.9 | |
Note: All assays to determine EC50 were conducted two to four times independently. The results are shown as means ± 1 standard deviation. The selectivity index (SI) is the ratio of CC50 and EC50 values.
CDV: cidofivir; ddC: zalcitabine; FdT: 3′-deoxy-3′-fluorothymidine; RBV: ribavirin; GCV: ganciclovir.