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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Ophthalmology. 2019 Sep 30;127(3):394–409. doi: 10.1016/j.ophtha.2019.09.035

Figure 10. Screening for iRORA using an en face slab with boundaries beneath the retinal pigment epithelium (RPE) to detect hypertransmission into the choroid using swept source (SS) OCT imaging.

Figure 10.

6×6 mm SS OCTA images of a right eye with large drusen. Panels A and B depict the eye at baseline and panels C and D show progression after 6 months. A: En face structure image using custom sub-RPE slab depicted by the purple boundary lines in B, and the bright area (yellow arrow) corresponds to the area of hypertransmission shown in B. B: SS-OCT B-scan showing a large druse with hypertransmission (yellow arrow). The boundary lines for the sub-RPE slab are shown beneath the RPE. There is loss of the photoreceptor-attributable bands, but the RPE remains intact, and as such, criteria for iRORA have not been met. C: Six months later, an en face structure image using the same custom sub-RPE slab depicted in panel A, but with a brighter area (blue arrow) corresponding to the area of hypertransmission shown in panel D. D: SS-OCT B-scan showing the collapse of the large druse with hypertransmission (lower blue arrow), disruption of the outer retinal layers (upper blue arrow) and a small disruption in the RPE can be seen. All criteria for iRORA have been reached.