Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 May 12;11(3):e00365-20. doi: 10.1128/mBio.00365-20

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Rybak et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

PMC Copyright notice

FIG 6 — Decreased intracellular accumulation of [³H]fluconazole among fluconazole-evolved strains. [³H]-labeled fluconazole uptake was determined in (a) fluconazole-evolved strains and (b) a CDR1 deletion strain and was compared to that shown by parental clinical isolate AR0387. FLU, fluconazole. Error bars for each data point represent standard deviations of results from six independent measurements of technical replicates. Intracellular accumulation of [³H]fluconazole was significantly lower in FLU-A, FLU-A2, FLU-B, and FLU-C than in AR0387 (P = 0.0021, P < 0.0001, P < 0.0001, and P < 0.0001, respectively), while accumulation in FLU-C2 did not significantly differ from that seen in AR0387 (P = 0.2842) and no difference in accumulation between AR0387 and AR0387_Δcdr1 was seen (P = 0.9976|).