Table 1.
Characteristics of Included Retrospective Studies.
| Study | Data source | Total participants | Duration | Dose | Relative risk of “cancer” ± RT |
|---|---|---|---|---|---|
| Meulepas et al14 | Dutch Pediatric CT Study | 168 394 | 1979-2014 | Mean cumulative RMB = 9.5 mGy; brain dose = 38.5 mGy | RR: 1.47; 95% CI: 1.34-1.61 Brain cancer—RR: 2.05; 95% CI: 1.48-2.83 Leukemia—RR: 1.39; 95% CI: 1.13-1.70 |
| Gonzalez et al13 | National Health Service Central Register | 178 601 | 1980-2008 | Mean cumulative RMB = 12 mGy; HL = 8 mGy | RR: 0.92; 95% CI: 0.38-2.22 |
| Nordenskjold et al15 | Karolinska University Hospital | 26 370 | 1973-1992 | Brain: 7.3-25.7 mGy | RR: 2.28; 95% CI: 1.56-3.33 |
| Krille et al16 | German Childhood Cancer Registry | 44 584 | 1966-2008 | NA | RR: 1.82; 95% CI: 1.29-2.50 Brain cancer—RR: 1.35; 95% CI: 0.54-2.78 Leukemia—RR: 1.72; 95% CI: 0.89-3.01 |
| Journy et al17 | One of 23 radiology departments | 58 620 | 2000-2010 | NA | RR: 1.05; 95% CI: 0.95-1.09 Brain cancer—RR: 0.9; 95% CI: 0.70-1.16 Leukemia—RR: 1.12; 95% CI: 0.84-1.52 |
| Huang et al18 | National Health Insurance Research database | 24 418 | NA | NA | RR: 1.29; 95% CI: 0.90-1.85 Brain cancer—RR: 2.67; 95% CI: 0.75-9.45 Leukemia—RR: 1.33; 95% CI: 0.14-12.8 |
| Mathews et al19 | Electronic Medicare Records | 680 000 | Average 9.5 years | RR: 1.24; 95% CI: 1.20-1.29 Brain cancer—RR: 2.13; 95% CI: 1.88-2.41 Leukemia—RR: 1.19; 95% CI: 1.03-1.37 |
Abbreviations: CT, computed tomography; HL, Hodgkin Lymphoma; RMB, red bone marrow dose; RR, relative risk; RT, radiotherapy. Bold values indicates p<0.01.