Table 1.
Monogenic Defects Underlying Narrow Susceptibility to Human Viral Diseases
| Outcome | Pathogen (condition) | Gene |
|---|---|---|
| Susceptibility | Influenza virus (severe pneumonia) | IRF7 |
| IRF9 | ||
| TLR3 | ||
| Rhinovirus (severe pneumonia) | IFIH1 | |
| Herpes simplex virus 1 (encephalitis) | UNC93B1 | |
| TLR3 | ||
| TRIF | ||
| TRAF3 | ||
| TBK1 | ||
| IRF3 | ||
| SNORA31 | ||
| Herpes simplex virus 1, influenza virus, norovirus (brainstem encephalitis) | DBR1 | |
| Beta-papillomavirus (skin warts and cancer) | TMC6 | |
| TMC8 | ||
| CIB1 | ||
| Epstein-Barr virus (hemophagocytosis, lympho-proliferation, lymphoma, hypogammaglobulinemia) | SH2D1A | |
| XIAP | ||
| ITK | ||
| MAGT1 | ||
| CD27 | ||
| CD70 | ||
| Varicella-zoster virus (disseminated disease) | POLR3A | |
| POLR3C | ||
| Human herpes virus-8 (Kaposi sarcoma) | TNFRSF4 | |
| Cytomegalovirus (disseminated disease) | NOS2 | |
| Hepatitis A virus (fulminant hepatitis) | IL18BP | |
| Live-attenuated measles or yellow fever vaccine (disseminated disease) | IFNAR1 | |
| IFNAR2 | ||
| STAT2 | ||
| IRF9 | ||
| Resistance | Human immunodeficiency virus | CCR5 |
| Norovirus | FUT2 |