Table 3.
Top 25 up- and down-regulated DEGs in the brain at 24 and 72 hpi.
| Up | Down | ||
|---|---|---|---|
| Blast2GO UniProt/SwissProt description | FC | Blast2GO UniProt/SwissProt description | FC |
| 24 hpi | |||
| Hydroxytryptamine receptor 3E (5HT3E5) | 51.82 | Prolactin (PRL) | −101144.45 |
| Bile acid-CoA:amino acid N-acyltransferase (BAAT) | 13.07 | Somatolactin (SL) | −13670.06 |
| Actin-related protein 2/3 complex subunit 1A(ARC1A) | 12.76 | Somatotropin (SOMA)–growht hormone (GH) | −2711.84 |
| Collagen alpha-1(X) chain (COAA1) | 10.87 | Gonadotropin subunit beta-2 (GTHB2) | −1896.99 |
| B2 bradykinin receptor (BKRB2) | 7.36 | O-acyltransferase like protein (OACYL) | −377.22 |
| Deoxyribonuclease-1 (DNAS1) | 6.95 | Pro-opiomelanocortin (POMC) | −349.84 |
| Deoxyribonuclease-1 (DNAS1) | 6.48 | Serotransferrin-1 (STF) | −240.04 |
| Alkaline phosphatase, tissue-nonspecific isozyme (PPBT) | 6.20 | Thyrotropin subunit beta (TSHB) | −172.68 |
| Proline-rich basic protein 1 (PROB1) | 4.78 | Gonadotropin alpha chain (GLHA) | −71.08 |
| Probable cysteine–tRNA ligase, mitochondrial (SYCM) | 4.68 | Transmembrane protein 130 (TM130) | −27.42 |
| MAGUK p55 subfamily member 4 (MPP4) | 4.34 | LINE-1 type transposase domain-containing protein 1 (LITD1) | −18.39 |
| Acidic repeat-containing protein (ACRC) | 4.20 | Pituitary-specific positive transcription factor 1 (PIT1) | −16.88 |
| Gag-Pol polyprotein (POL) | 4.14 | Troponin T, fast skeletal muscle isoforms (TNNT3) | −16.50 |
| MICAL-like protein 2 (MILK2) | 4.12 | Transcription factor COE1 (COE1) | −16.04 |
| Leucine-rich repeat and coiled-coil domain-containing protein 1 (LRCC1) | 4.07 | Methylmalonyl-CoA mutase, mitochondrial (MUTA) | −15.94 |
| Tetranectin (TETN) | 3.86 | Gonadotropin subunit beta-1 (GTHB1) | −12.59 |
| ATP-binding cassette sub-family A member 1 (ABCA1) | 3.81 | LINE-1 reverse transcriptase homolog (LIN1) | −10.49 |
| Oxysterol-binding protein-related protein 11 (OSB11) | 3.78 | Pituitary homeobox 3 (PITX3) | −10.15 |
| DNA replication complex GINS protein PSF3 (PSF3) | 3.58 | Myosin regulatory light chain 2, skeletal muscle isoform type 2 (MLRS) | −9.10 |
| Filamin-C (FLNC) | 3.57 | NLR family CARD domain containing 3 (NLRC3) | −8.70 |
| Leukocyte cell-derived chemotaxin-2 (LECT2) | 3.55 | LINE-1 retrotransposable element ORF2 protein (LORF2) | −8.66 |
| Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMH1) | 3.50 | UPF0577 protein KIAA1324 (K1324) | −8.58 |
| Protein largen (LARGN) | 3.41 | NADH dehydrogenase (NDUFA1) | −7.48 |
| High affinity choline transporter 1 (SC5A7) | 3.37 | Regulator of rDNA transcription protein 15 (RRT15) | −7.20 |
| Cathepsin D (CATD) | 3.36 | Fructose-bisphosphate aldolase A (ALDOA) | −6.90 |
| 72 hpi | |||
| Prolactin (PRL) | 4713.60 | Myosin regulatory light chain 2, skeletal muscle isoform type 2 (MLRS) | −47.94 |
| Somatotropin (SOMA) | 1332.49 | Collagen alpha-1(II) chain (CO2A1) | −34.45 |
| Thyrotropin subunit beta (TSHB) | 27.90 | Transposon Ty3-I Gag-Pol polyprotein (YI31B) | −30.32 |
| Probable cysteine–tRNA ligase, mitochondrial (SYCM) | 25.81 | Fructose-bisphosphate aldolase A (ALDOA) | −19.98 |
| Gonadotropin alpha chain (GLHA) | 19.53 | Troponin T, fast skeletal muscle isoforms (TNNT3) | −18.43 |
| Pentraxin-4 (PTX4) | 13.24 | Sodium channel protein type 4 subunit alpha B (SC4AB) | −14.00 |
| Pro-opiomelanocortin (POMC) | 13.23 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (AT2A1) | −13.68 |
| LINE-1 retrotransposable element ORF2 protein (LORF2) | 10.99 | Creatine kinase M-type (KCRM) | −12.46 |
| Serine protease 48 (PRS48) | 9.97 | Actin, alpha skeletal muscle 2 (ACT2) | −11.73 |
| Probable E3 ubiquitin-protein ligase HERC4 (HERC4) | 8.55 | Keratin, type I cytoskeletal 17 (K1C17) | −11.31 |
| Sacsin (SACS) | 7.07 | Parvalbumin alpha (PRVA) | −10.45 |
| C-X-C motif chemokine 9 (CXCL9) | 7.07 | Collagen alpha-1(II) chain (CO2A1) | −9.10 |
| Radical S-adenosyl methionine domain-containing protein 2 (RSAD2) | 6.63 | Keratin, type I cytoskeletal 13 (K1C13) | −8.06 |
| Sacsin (SACS) | 6.37 | DNA damage-inducible transcript 4-like protein (DDT4L) | −5.60 |
| Receptor-transporting protein 3 (RTP3) | 5.81 | Receptor-type tyrosine-protein phosphatase F (PTPRF) | −5.58 |
| Receptor-type tyrosine-protein phosphatase F (PTPRF) | 5.75 | Metabotropic glutamate receptor 8 (GRM8) | −5.54 |
| Complement C3 (CO3) | 5.66 | Alpha-1B adrenergic receptor (ADA1B) | −5.46 |
| Protein quaking-A (QKIA) | 5.57 | Sodium channel protein type 4 subunit alpha B (SC4AB) | −5.30 |
| Inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2) | 5.03 | Amiloride-sensitive amine oxidase (AOC1) | −5.15 |
| LINE-1 retrotransposable element ORF2 protein (LORF2) | 5.02 | DNA damage-inducible transcript 4-like protein (DDT4L) | −5.03 |
| Dynein heavy chain 8, axonemal (DYH8) | 4.99 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (NDST3) | −5.02 |
| Retrovirus-related Pol polyprotein from transposon 412 (POL4) | 4.73 | Leukocyte cell-derived chemotaxin-2 (LECT2) | −4.89 |
| Inter-alpha-trypsin inhibitor heavy chain H5 (ITIH5) | 4.50 | Leukocyte cell-derived chemotaxin 1 (CNMD) | −4.89 |
| WD repeat-containing protein on Y chromosome (WDY) | 4.43 | Feline leukemia virus subgroup C receptor-related protein 2 (FLVC2) | −4.83 |
| Filamin-C (FLNC) | 4.37 | Sulfotransferase family cytosolic 2B member 1 (ST2B1) | −4.79 |