Fig. 3.

Replacement and remediation results for translocations and UD^MEL. Time-series results are shown for a given number of weekly releases of 20 adult Ae. aegypti per household with the intent of population replacement or remediation in the community of Yorkeys Knob (Fig. 1c), and at given coverage levels, where coverage is the proportion of households that receive the releases. For population replacement, releases are of males homozygous for the translocation or UD^MEL into a wild-type population. For remediation of translocations, releases are of wild-type males into a population homozygous for the translocation. For UD^MEL, remediation is not possible through releases of males only, and so “mixed remediation” is considered, in which releases consist of 10 females and 10 males. (Top) Replacement and remediation are symmetric for translocations. At a coverage of 50%, seven or more releases result in the translocation being driven to fixation or remediated from the population. (Bottom) Release requirements for UD^MEL are smaller for population replacement, but larger for mixed remediation. At a coverage of 50%, a single release results in UD^MEL being driven to fixation