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. 2020 May 12;12:65. doi: 10.1186/s13148-020-00845-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1: — Study identification and selection process. Our search resulted in 314,467 records on EDCs. From these, 100,039 articles were on concept 1 (paternal aspects) and 17,664 were on concept 2 (next generation or offspring). The number of articles on associations between concept 1 and concept 2 resulted in 7283 articles. Inclusion of concept 3 (epigenetics) resulted 270 articles. Finally, 43 articles met our inclusion criteria and were considered in the present study