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. 2020 May 13;21:37. doi: 10.1186/s12860-020-00280-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — a: The heatmap of the differentially expressed genes. The top 10 up-and down-regulated genes were listed on the heatmap. b: Joyplot of the 7 up-regulated metabolism pathway and 23 down-regulated pathways. c: Dotplot referred to the same results of joyplot and the enrichment degree. d: Venn diagram indicating the common gene between extremely differential expression genes and all genes involved in purine metabolism. It showed that 3 genes were the common genes