Table 1.

Joinpoint analysis of trends in age-standardized event rates of diabetes-related complications in men with diabetes

Complications	Event rates (per 10,000)			Time period 1		Time period 2		Time period 3
	2001	2016	AAPC (95% CI)	Year	APC (95% CI)	Year	APC (95% CI)	Year	APC (95% CI)
CHD
All ages	477.3	146.0	− 7.6 (− 10.2, − 5.0)*	2001–2003	− 23.1 (− 38.8, − 3.3)*	2003–2016	− 5.0 (− 6.0, − 4.0)*
20–44 years	155.9	55.1	− 7.3 (− 15.0, 1.1)	2001–2003	− 32.2 (− 66.1, 35.7)	2003–2016	− 2.7 (− 6.0, 0.68)
45–64 years	651.9	199.8	− 7.6 (− 9.5, − 5.7)*	2001–2003	− 22.6 (− 32.2, − 11.7)*	2003–2007	− 7.5 (− 12.9, − 1.9)*	2007–2016	− 3.9 (− 4.9, − 3.0)*
65–74 years	914.3	217.1	− 9.0 (− 11.1, − 6.8)*	2001–2006	− 13.7 (− 15.8, − 11.5)*	2006–2010	− 3.1 (− 8.4, 2.6)	2010–2016	− 8.9 (− 10.5, − 7.3)*
≥ 75 years	813.3	281.1	− 6.5 (− 8.7, − 4.2)*	2001–2006	− 9.3 (− 13.7, − 4.6)*	2006–2010	3.6 (− 4.5, 12.4)	2010–2016	− 10.4 (− 12.5, − 8.3)*
Stroke
All ages	339.5	100.9	− 8.7 (− 9.8, − 7.5)*	2001–2005	− 15.3 (− 19.0, − 11.3)*	2005–2016	− 6.2 (− 7.1, − 5.2)*
20–44 years	56.2	50.3	− 1.8 (–4.6, 1.1)	2001–2016	− 1.8 (− 4.6, 1.1)
45–64 years	338.2	99.7	− 8.3 (− 9.6, − 7.1)*	2001–2005	− 16.3 (− 20.4, − 12.0)*	2005–2016	− 5.3 (− 6.1, − 4.4)*
65–74 years	788.5	157.5	− 10.5 (− 11.5, − 9.5)*	2001–2005	− 15.4 (− 18.8, − 12.0)*	2005–2016	− 8.7 (− 9.5, − 7.9)*
≥ 75 years	1224.8	289.0	− 9.6 (− 10.6, − 8.6)*	2001–2005	− 14.8 (− 18.3, − 11.1)*	2005–2016	− 7.6 (− 8.3, − 7.0)*
Heart failure
All ages	228.6	83.1	− 6.4 (− 8.0, − 4.7)*	2001–2005	− 12.8 (− 18.3, − 7.0)*	2005–2016	− 3.9 (− 5.2, − 2.7)*
20–44 years	41.6	30.8	1.2 (− 2.4, 4.8)	2001–2016	1.2 (− 2.4, 4.8)
45–64 years	147.5	56.6	− 5.8 (− 8.1, − 3.5)*	2001–2006	− 13.7 (− 19.7, − 7.3)*	2006–2016	− 1.6 (− 3.7, 0.52)
65–74 years	431.9	116.4	− 8.5 (− 10.0, − 7.1)*	2001–2009	− 11.3 (− 13.3, − 9.2)*	2009–2016	− 5.3 (− 7.9, − 2.7)*
≥ 75 years	1259.2	413.4	− 6.9 (− 8.7, − 5.1)*	2001–2005	− 13.0 (− 19.3, − 6.2)*
Hyperglycaemic crisis
All ages	81.5	33.3	− 6.6 (− 12.4, − 0.44)*	2001–2003	− 30.0 (− 57.9, 16.6)	2003–2016	− 2.4 (− 4.9, 0.24)
20–44 years	151.7	66.0	− 3.9 (− 6.2, − 1.5)*	2001–2016	− 3.9 (− 6.2, − 1.5)*
45–64 years	25.4	10.1	− 7.0 (− 10.6, − 3.2)*	2001–2005	− 22.3 (− 33.0, − 9.9)*	2005–2016	− 0.7 (− 3.5, 2.2)
65–74 years	23.2	4.0	− 12.2 (− 16.3, − 7.9)*	2001–2003	− 42.7 (− 60.4, − 17.2)*	2003–2016	− 6.2 (− 8.4, − 4.0)*
≥ 75 years	42.3	5.5	− 13.2 (− 17.8, − 8.5)*	2001–2004	− 31.4 (− 48.0, − 9.5)*	2004–2016	− 8.0 (− 10.7, − 5.3)*
LEA
All ages	36.0	11.7	− 5.8 (− 7.2, − 4.4)*	2001–2016	− 5.8 (− 7.2, − 4.4)*
20–44 years	14.1	3.8	− 7.4 (− 19.5, 6.5)	2001–2006	− 8.7 (− 22.4, 7.5)	2006–2010	14.5 (− 17.5, 59.0)	2010–2016	− 18.9 (− 27.5, − 9.3)*
45–64 years	37.5	18.4	− 2.8 (− 4.7, − 0.91)*	2001–2016	− 2.8 (− 4.7, − 0.91)*
65–74 years	48.0	16.4	− 8.0 (− 9.5, − 6.5)*	2001–2016	− 8.0 (− 9.5, − 6.5)*
≥ 75 years	123.0	16.6	− 10.5 (− 12.1, − 8.9)*	2001–2016	− 10.5 (− 12.1, − 8.9)*

CHD coronary heart disease, LEA lower-extremity amputation, AAPC average annual percent change, APC annual percent change

* P < 0.05