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. Author manuscript; available in PMC: 2020 Oct 7.
Published in final edited form as: Nat Med. 2019 Oct 7;25(10):1512–1518. doi: 10.1038/s41591-019-0598-9

Fig 4.

Fig 4

In vivo histology. Hematoxylin and eosin stained swine small intestine tissue taken at the site of actuation. The top row represents a full tissue slice and the bottom row shows a zoomed in portion marked by the rectangular outline. From left to right: a 32 G hypodermic needle coated in blue dye was manually inserted into the tissue (dye is a surrogate for needle insertion depth, as no hole in the tissue was seen); a LUMI with microneedles unfolded and made contact with the tissue; a microneedle patch was manually applied to the tissue; a LUMI without microneedles unfolded and made contact with the tissue; a control piece of tissue where no device was applied. SM = Submucosa. Mu = Muscularis Externa. Scale Bars = 0.5 mm (top) 0.1 mm (bottom).