Table 1.
Effect of alcohol on different immune cells and MS
| Cell type | Effect | |
|---|---|---|
| Lymphocytes | decreased the size and cell number of lymphocyte (T cell) in the thymus, spleen, and lymph nodes [21,22] | |
| NK cell | reduction of the amount and activity of large granular lymphocyte/NK cells, suppress the activity of NK cells [51] | |
| APCs | Impaired delayed-type hypersensitivity response, decrease in monocyte antigen-presenting cell function [55] | |
| DC | inhibited monocyte-derived myeloid dendritic cell capacity [106] | |
| Cytokines | Inflammatory | reduces IFN-gamma levels [75] |
| Auto-inflammatory | increase in IL-10 levels, release TGF beta (inhibiting T cell proliferation and decreasing cytokine production in monocytes) [103] | |