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. 2020 May 13;17:11. doi: 10.1186/s12979-020-00182-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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F ig. 2 — Results of the GSEA analysis. (a and b) Dot plots of GSEA results illustrating GO biological processes associated with HERV-K (HML-2) provirus 1q22 expression in both nonagenarian individuals and young controls respectively. The figures show the significant top 15 positively and the top 15 negatively enriched GO terms, based on co-expressed genes. There were only 12 significantly downregulated GO biological processes for the young. Gene count refers to the number of genes associated with each GO biological process. Gene ratio is the percentage of genes that significantly correlated with 1q22 expression from the total number of genes associated to that process. Terms are ranked in the figure by decreasing gene ratio. One GO term, “neutrophil activation”, directly involves neutrophil function and is bolded in the figure. (c) GSEA plot indicating enrichment of the biological process of neutrophil activation in the nonagenarians, based on the concentration of neutrophil activation –related genes at the beginning of the gene list ordered by correlation with 1q22 expression