Table 1.
For nonagenarian samples, the GO biological processes that were most significantly associated with HERV-K (HML-2) provirus 1q22 expression, ordered by p-value. Enrichment score for each GO biological process is determined through GSEA, as shown in Fig. 2. Set size refers to the total number of the studied genes associated to each process, while gene ratio is the number of those genes that strongly correlated with 1q22 expression. The GO terms that are directly involved in neutrophil functions are in bold
| ID | Description | p-value | Adjusted p-value | FDR (q-value) | Enrichment | Gene ratio | Set size |
|---|---|---|---|---|---|---|---|
| GO:0051050 | positive regulation of transport | 1.51E-05 | 7.07E-04 | 4.62E-04 | 0.283 | 37% | 490 |
| GO:0023014 | signal transduction by protein phosphorylation | 1.51E-05 | 7.07E-04 | 4.62E-04 | 0.262 | 37% | 472 |
| GO:0061024 | membrane organization | 1.51E-05 | 7.07E-04 | 4.62E-04 | 0.303 | 44% | 467 |
| GO:0050778 | positive regulation of immune response | 1.52E-05 | 7.07E-04 | 4.62E-04 | 0.297 | 39% | 464 |
| GO:0002274 | myeloid leukocyte activation | 1.52E-05 | 7.07E-04 | 4.62E-04 | 0.425 | 46% | 459 |
| GO:0044257 | cellular protein catabolic process | 1.52E-05 | 7.07E-04 | 4.62E-04 | 0.279 | 37% | 451 |
| GO:0031347 | regulation of defense response | 1.52E-05 | 7.07E-04 | 4.62E-04 | 0.287 | 41% | 444 |
| GO:0017144 | drug metabolic process | 1.53E-05 | 7.07E-04 | 4.62E-04 | 0.277 | 32% | 430 |
| GO:0019221 | cytokine-mediated signaling pathway | 1.53E-05 | 7.07E-04 | 4.62E-04 | 0.282 | 41% | 425 |
| GO:0002444 | myeloid leukocyte mediated immunity | 1.54E-05 | 7.07E-04 | 4.62E-04 | 0.448 | 47% | 405 |
| GO:0002275 | myeloid cell activation involved in immune response | 1.54E-05 | 7.07E-04 | 4.62E-04 | 0.447 | 47% | 398 |
| GO:0098657 | import into cell | 1.54E-05 | 7.07E-04 | 4.62E-04 | 0.334 | 46% | 396 |
| GO:0043299 | leukocyte degranulation | 1.54E-05 | 7.07E-04 | 4.62E-04 | 0.451 | 48% | 394 |
| GO:0036230 | granulocyte activation | 1.55E-05 | 7.07E-04 | 4.62E-04 | 0.462 | 49% | 381 |
| GO:0042119 | neutrophil activation | 1.55E-05 | 7.07E-04 | 4.62E-04 | 0.461 | 49% | 378 |
| GO:0002446 | neutrophil mediated immunity | 1.55E-05 | 7.07E-04 | 4.62E-04 | 0.463 | 49% | 377 |
| GO:0002283 | neutrophil activation involved in immune response | 1.55E-05 | 7.07E-04 | 4.62E-04 | 0.466 | 49% | 370 |
| GO:0043312 | neutrophil degranulation | 1.55E-05 | 7.07E-04 | 4.62E-04 | 0.466 | 49% | 370 |
| GO:0006897 | endocytosis | 1.55E-05 | 7.07E-04 | 4.62E-04 | 0.331 | 46% | 367 |
| GO:0002253 | activation of immune response | 1.56E-05 | 7.07E-04 | 4.62E-04 | 0.304 | 39% | 368 |