Fig. 3.

H19 acts as a molecular “sponge” for let-7. (a) The microRNA let-7 functions as a negative regulator of target genes [36]. (b) We have shown that H19 acts as a molecular “sponge” for let-7, binding and modulating its availability [36]. The Amh mRNA contains putative binding sites for let-7 [14], and let-7 transfection leads to decreased Amh expression in GCs [14], supporting Amh as a novel let-7 target and representing a novel ncRNA mediated mechanism by which the bioavailability of Amh can be regulated by H19