S2. P value of coefficients in handcrafted radiomics signature.

Features	Coefficient	P
GLSZM, gray level size zone matrix; SALGLE, small area low gray level emphasis; GLCM, gray level co-occurrence matrix; GLRLM, gray level run length matrix; LRHGLE, long run high gray level emphasis; LoG, laplacian of gaussian.
bior2.8_LH_GLSZM_SALGLE	8.037	0.0430
bior3.7_LL_ GLCM_energy	1.502	0.0009
bior6.8_HL_GLRLM_LRHGLE	−0.006	0.0130
coif5_LL_GLCM_energy	−12.186	0.0490
db8_HL_GLSZM_SALGLE	−15.893	0.0110
LoG_1.5_GLCM_correlation	−0.905	0.0440
LoG_1.0_ GLSZM_SALGLE	−2.470	0.0140